Everybody is seeking the fountain of youth, hoping to turn back the clock, or at least slow it down.  More and more supplements are on the market claiming the ability to reduce and reverse aging.  Getting to the truth is becoming too challenging and requires an incredible amount of time and research. Today we are going to break it down and take an in-depth look at one of most highly rated health, aging, and Mind rejuvenating supplements on the market.  In our complete LifeVantage Protandim Side Effects and Review, we will help you determine if the benefits of using this supplements are worth it.

lifevantage protandim Review

What is Protandim?

Protandim is LifeVantage’s flagship product or products.  Protandim is actually 2 products.  They are Protandim NRF1 Synergizers and Protandim NRF2 Synergizers and they both have completely different functions.

Protandim NFR1 is designed to cultivate energy for the body and mind.  As the body ages, it slows or stops producing the Mitochondria, which are the cell’s batteries.  When this slows, fatigue sets in.  NFR1 maintains the Mitochondria production to help you feel more energetic and healthier both inside and out.

Protandim NFR2 reduces oxidative stress in the body.  By helping the cells produce antioxidants, NFR2 is clinically proven to decrease the OS by 40% in 30 days.  As we age, taking “supplements” and juicing will not replenish the depleting antioxidants at a high enough rate.  NFR2 is able to neutralize free radicals to give you the ability to live a vibrant and healthy life.

What are the Ingredients?

lifevantage protandim Review NFR1

Protandim NFR1 Ingredients:


An amino acid (a building block for proteins) that is naturally produced in the body. Acetyl L-Carnitine enhances either mitochondrial DNA (mtDNA) transcription, the stability of mitochondrial mRNA, or mitochondrial protein synthesis. Combined with Alpha Lipoic Acid, these two ingredients boost mitochondria production, support healthy cellular aging, and protect against normal oxidation of RNA and mitochondria.*


Quercetin is a naturally occurring antioxidant, a flavonoid that is abundant in various fruits and vegetables. It is a NRF1 activator that promotes mitochondria biogenesis and helps support normal mitochondrial function. Quercetin is a polyphenol that helps to protect the mitochondria and their function—which supports ATP synthesis.*


Alpha lipoic acid, or ALA, is made in the body and helps to turn glucose into energy that the cell can use. ALA is able to neutralize free radicals because of its -thiol groups because it is both fat and water soluble, it can protect all parts of the cell (including the mitochondria) from these free radicals.*


This extract contains powerful natural Stilbenoids (Resveratrol and viniferin) known to have anti-aging capabilities by activating the NRF1 protein and other anti-aging pathways.*


It is made in the body and resides primarily in mitochondria where it plays a key role in transporting electrons so ATP is made. Combined with Alpha Lipoic Acid, it supports cellular energy levels, stress response and antioxidant defense mechanisms.*


Vegetable Capsule
Hydroxypropyl Methylcellulose, Magnesium Stearate.

*100% Vegetarian. Free of Gluten, Wheat, and Dairy.

Protandim NFR2 Ingredients

lifevantage protandim Review-protandim-nrf2


Turmeric is a common spice and a plant that is in the ginger family.  It has been used in both Ayurvedic and Chinese medicine to help a variety of conditions such as breathing problems, rheumatism, serious pain, and fatigue. Current uses are as a dietary supplement for inflammation; arthritis; stomach, skin, liver, and gallbladder problems; cancer; and other conditions. Turmeric is known to contain natural phenols called curcuminoids.


Bacopa has long been hailed for its ability to enhance cognitive abilities and also thought as an aid to treat Alzheimer’s disease, memory loss, anxiety, attention deficit-hyperactivity disorder. Bacopa has been important in Ayurvedic medicine for centuries, used chiefly to enhance clear thinking and memory function. Studies suggest it provides strong cellular defense. It is also used to improve concentration, alertness, and focus. The bacopa ingredient in Protandim is high in bacosides, the major constituent of which is the botanical compound called saponins.


Called the “king of Ayurvedic herbs,” and is known as Indian ginseng.  Ashwagandha is an adaptogen (a substance which enhances the resistance of an organism to various stressors) and has been traditionally used as an anxiolytic to help reduce chronic stress. It’s top 5 benefits are improved Thyroid function, relieved adrenal fatigue, lowering stress and anxiety, improves depression, and balancing of blood sugars.  Ashwagandha has also been used as a way to support memory enhancement and as a sleep aid. The primary active components in Ashwagandha are a group of chemical compounds called withanolides.


Green tea is made from unfermented leaves and reportedly contains the highest concentration of powerful antioxidants called polyphenols, particularly catechins, of which epigallocatechin gallate (EGCG) is the most abundant. They help prevent cellular damage. Protandim’s green tea extract contains 98% polyphenols. Green tea has been traditionally used for many health benefits, including regulating body temperature and blood sugar, promoting digestion, improving mental processes and improving cardiovascular health.


Milk thistle is related to the daisy and ragweed family.  It has been used as an herbal remedy to support liver, kidney and gallbladder function. Several scientific studies suggest that substances in milk thistle (especially a flavonoid called silymarin) protect the liver from toxins, aid the heart by lowering cholesterol and help individuals with type 2 diabetes.

*100% Vegetarian. Free of Gluten, Wheat, and Dairy.

lifevantage protandim Review ingredients NFR2lifevantage protandim Review facts-protandim-nrf1

What are the benefits?

These are the top benefits found by taking both NFR1 and NFR2


  • Improve performance through energy production
  • Enhance cellular health—cells function at peak performance
  • Increase cellular energy (ATP)
  • Boost mitochondria production and their ability to network


  • Reducing oxidative stress by 40% in just 30 days
  • Significantly reducing cellular stress through Nrf2 activation
  • Producing enzymes capable of neutralizing more than 1,000,000 free radicals
  • Helping to regulate survival genes
  • Helping the body repair and rejuvenate its own cells
  • Helping the body detoxify genes, keeping the master blueprint of the cell’s function intact

How does Protandim work?

Combining Protandim NFR1 and Protandim NFR2 together gives the body the greatest benefits.  NFR1 has 5 main functions that benefit the body.  NFR1 increases ATP production which boosts energy levels of vital organs at the cellular level.  Increased cellular energy allows the body to function at its highest level of efficiency.

Activate NFR1 Protein – By bringing to life the NFR1 Protein, the body begins to create more mitochondria which leads to a Boost of Mitochondria production.  Increased Mitochondria in the cells helps the body’s efficiency.  A few of these positive side effects are improved cellular rejuvenation and heme production, along with improved brain function, cognitive health, and supporting heart health.

Protandim NFR2 aids in the body’s healing and rejuvenation of cells and genes.

Activates the NFR2 protein that is going to help maintain and control your body’s stress response.  The NFR2 protein is the chief regulator of this stress response which allows for the creation of the body’s own protective antioxidant enzymes: superoxide dismutase, heme-oxygenase, glutathione peroxidase and catalase.

Combining both Protandim NFR1 and Protandim NFR2 reduces oxidative stress which is going to have a significant effect on cellular health.

What are the side effects?

LifeVantage does not expect any side effects when taking Protandim, however, some people may have an allergic reaction to one or more of the ingredients.  known allergic reactions include the following symptoms:

  • Stomach ache and diarrhea
  • Headache
  • Rash or redness on the hands/feet

The side effects have been noted to disappear when stopping taking Protandim.  And LifeVantage recommends stopping usage if any of the above symptoms occur.

Where can you buy it?

LifeVantage allows you to order directly from their site and they will assign a personal distributor to assist or you can choose your own LifeVantage representative. 

To make things easier, I’ve put together a list of active LifeVantage distributors who can answer any questions, provide additional resources, and help you place your first order. CLICK HERE or the image to find your personal representative.

While the product can occasionally be found on Amazon, they work diligently to make sure all orders go directly through the corporate office.  We never suggest purchasing from outside of a direct tie to the company as they will not accept returns from third-party retailers of LifeVantag’s Protandim or any of their products.  Additionally, LifeVantage cannot be held liable for the quality or production of the product as they do not endorse this form of distribution.

LifeVantage Independent Distributor

What does it cost?

There are 2 ways to purchase Protandim, either Retail or on a monthly subscription.  Our suggestion is to get on their monthly shipment as you receive the greatest savings on the supplements by as much as 30%.

See the cost breakdown below

Monthly subscription (20% savings over retail)

Protandim NFR1 is $40.99/month 

Protandim NFR2 is 45/month

Protandim Dual Synegizer (both nfr1 and nfr2) costs $ 85.99/month

Retail Price

NFR1 is $59/month

NFR2 is 50.99/month

Protandim Dual Synegizer (both nfr1 and nfr2) costs $ 102.99/month

lifevantage protandim Review product-protandim-dual

Our conclusion

In our LifeVantage Protandim Review, we have found that Protandim (NFR1 and NFR2)  seem to be a solid and complete supplement solution for restoring health and mind function.  For its price and what the clinical’s report, LifeVantage’s Protandim is a solid choice to aid in cognitive and health functions. Whether it will completely stop or reverse aging remains to be seen and we do not think this is the case, however, what Protandim does do has proven to be highly beneficial.  In regards to the ingredients, they appear to be helpful in their nature and work to improve/restore bodily functions.  While some might not like having to purchase from a distributor, this allows the company to keep its product at the highest level of quality and keep advertising costs lower. While not evaluated by the FDA, it is important to note that FDA evaluates nor puts a stamp of approval on supplements.

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